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11 p, 21.0 MB |
Analysis of Tumor Microenvironment Changes after Neoadjuvant Chemotherapy with or without Bevacizumab in Advanced Ovarian Cancer (GEICO-89T/MINOVA Study)
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Tavira, Beatriz (Cancer Center Clínica Universidad de Navarra) ;
Iscar, Teresa (Cancer Center Clínica Universidad de Navarra) ;
Manso, Luis (Hospital 12 de Octubre (Madrid)) ;
Santaballa, Ana (Hospital Universitari i Politècnic La Fe (València)) ;
Gil-Martin, Marta (Institut Català d'Oncologia - Hospital Duran i Reynals) ;
García García, Yolanda (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iglesias, Maria (Hospital Son Llátzer) ;
de Juan Ferre, Ana (Hospital Marqués de Valdecilla) ;
Barretina-Ginesta, Maria-Pilar (Institut Català d'Oncologia) ;
Manzano, Aranzazu (Hospital Clínico San Carlos (Madrid)) ;
Gaba, Lydia (Hospital Clínic i Provincial de Barcelona) ;
Rubio, Maria Jesus (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
de Andrea, Carlos E. (Centro de Investigación Biomédica en Red de Cáncer) ;
González-Martín, Antonio (Cancer Center Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona
The aim of our study was to elucidate the impact of bevacizumab added to neoadjuvant chemotherapy (NACT) on the tumor immune microenvironment and correlate the changes with the clinical outcome of the patients. [...]
2023 -  10.1158/1078-0432.CCR-23-0771
Clinical Cancer Research, Vol. 30 (august 2023) , p. 176-186
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9 p, 442.2 KB |
B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy
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Woyach, Jennifer A. (The Ohio State University Comprehensive Cancer Center, Columbus, Ohio) ;
Ghia, Paolo (Universita Vita-Salute San Raffaele, Milan, Italy) ;
Byrd, John C. (University of Cincinnati College of Medicine, Cincinnati, Ohio) ;
Ahn, Inhye E. (Laboratory of Lymphoid Malignancies, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland) ;
Moreno, Carol (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brien, Susan M. (UC Irvine. Chao Family Comprehensive Cancer Center, Irvine, California) ;
Jones, Daniel (The Ohio State University Comprehensive Cancer Center, Irvine, California) ;
Cheung, Leo W.K. (Pharmacyclics LLC, an AbbVie Company, South San Francisco, California) ;
Chong, Elizabeth (Pharmacyclics LLC, an AbbVie Company, South San Francisco, California) ;
Kwei, Kevin (Pharmacyclics LLC, an AbbVie Company, South San Francisco, California) ;
Dean, James P. (Pharmacyclics LLC, an AbbVie Company, South San Francisco, California) ;
James, Dannelle F. (Pharmacyclics LLC, an AbbVie Company, South San Francisco, California) ;
Wiestner, Adrian (Laboratory of Lymphoid Malignancies, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland)
Purpose: Acquired mutations in Bruton's tyrosine kinase (BTK) or phospholipase C-γ2 (PLCG2) genes are associated with clinical progressive disease (PD) in patients with chronic lymphocytic leukemia (CLL) treated with BTK inhibitors. [...]
2023 - 10.1158/1078-0432.CCR-22-3887
Clinical Cancer Research, Vol. 29 Núm. 16 (august 2023) , p. 3065-3073
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14 p, 1.6 MB |
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers
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Blanco, Belén (Red Española de Terapias Avanzadas (TERAV)) ;
Ramírez-Fernández, Ángel (Immuno-Oncology and Immunotherapy Group. Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Argemí-Muntadas, Lidia (Aarhus University, Denmark) ;
Fuentes, Patricia (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Aguilar-Sopeña, Óscar (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Gutierrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zanetti, Samanta Romina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tapia-Galisteo, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Díez-Alonso, Laura (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Segura-Tudela, Alejandro (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Castellà, Maria (Hospital Clínic i Provincial de Barcelona) ;
Marzal, Berta (Hospital Clínic i Provincial de Barcelona) ;
Betriu-Méndez, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Harwood, Seandean L. (Aarhus University, Denmark) ;
Compte, Marta (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Lykkemark, Simon (Aarhus University, Denmark) ;
Erce-Llamazares, Ainhoa (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Rubio-Pérez, Laura (Universidad Francisco de Vitoria (UFV). Pozuelo de Alarcón) ;
Jiménez-Reinoso, Anaïs (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Domínguez-Alonso, Carmen (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Neves, Maria (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Morales, Pablo (Hospital 12 de Octubre (Madrid)) ;
Paz-Artal, Estela (Department of Immunology Ophthalmology and ENT. School of Medicine. Universidad Complutense) ;
Guedan, Sonia (Hospital Clínic i Provincial de Barcelona) ;
Sanz, Laura (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Toribio, Maria L. (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Roda-Navarro, Pedro (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Vallina, Luis (Hospital 12 de Octubre (Madrid))
Chimeric antigen receptor (CAR)-modified T cells have revolutionized the treatment of CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous T cells can induce remission in patients with B-cell acute lymphoblastic leukemia, a large subset relapse, most of them with CD19-positive disease. [...]
2022 - 10.1158/2326-6066.CIR-21-0853
Cancer Immunology Research, Vol. 10 Núm. 4 (april 2022) , p. 498-511
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19 p, 8.1 MB |
Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
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Franco Valls, Héctor (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Tusquets Uxó, Elsa (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Sala, Laura (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Val, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peña, Raúl (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Iaconcig, Alessandra (International Centre for Genetic Engineering and Biotechnology (ICGEB)) ;
Villarino, Álvaro (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Jiménez Arriola, Martín (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Massó, Pere (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Eyras, Eduardo (John Curtin School of Medical Research. Australian National University) ;
Muro, Andrés F. (International Centre for Genetic Engineering and Biotechnology (ICGEB)) ;
Otero, Jorge (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Garcia de Herreros, Antonio (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Baulida, Josep (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM))
Background: As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy stromal cells. [...]
2023 - 10.1186/s13058-023-01736-y
Breast cancer research, Vol. 25 Núm. 1 (december 2023) , p. 143
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14 p, 563.4 KB |
Clinical management of epidermal growth factor receptor mutation-positive non-small cell lung cancer patients after progression on previous epidermal growth factor receptor tyrosine kinase inhibitors : The necessity of repeated molecular analysis
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González-Larriba, José Luis (Hospital Universitario Clínico San Carlos (Madrid)) ;
Lázaro-Quintela, Martín (Complexo Hospitalario Universitario de Vigo) ;
Cobo, Manuel (Hospital Regional Universitario de Málaga) ;
Dómine, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Universitat Autònoma de Barcelona
One of the most important advances in the treatment of non-small cell lung cancer (NSCLC) has been the identification of molecular alterations vulnerable to targeted inhibition, such as mutations in the epidermal growth factor receptor (EGFR) gene. [...]
2017 - 10.21037/tlcr.2017.10.03
Translational Lung Cancer Research, Vol. 6 (january 2017) , p. S21-S34
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30 p, 7.3 MB |
Single-Cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy
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Campillo-Marcos, Ignacio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Casado Pelaez, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mata, Caterina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Valcárcel, David (Vall d'Hebron Institut d'Oncologia) ;
Molero, Antonieta (Hospital Universitari Vall d'Hebron) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Acha, Pamela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Manzanares Mileo, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tobiasson, Magnus (Karolinska Institutet (Estocolm, Suècia)) ;
Hellström-Lindberg, Eva (Karolinska Institutet (Estocolm, Suècia)) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Alterations in epigenetic marks, such as DNA methylation, represent a hallmark of cancer that has been successfully exploited for therapy in myeloid malignancies. Hypomethylating agents (HMAs), such as azacitidine (AZA), have become standard-of-care therapy to treat myelodysplastic syndromes (MDS), myeloid neoplasms that can evolve into acute myeloid leukemia (AML). [...]
2024 - 10.1158/2767-9764.CRC-23-0389
Cancer Research Communications, Vol. 4 Núm. 2 (2024)
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11 p, 1.5 MB |
Intermittent androgen deprivation therapy : Recommendations to improve the management of patients with prostate cancer following the GRADE approach
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Bonfill, X. (Xavier) (Institut d'Investigació Biomèdica Sant Pau) ;
Arevalo-Rodriguez, Ingrid (Hospital Ramon y Cajal (IRYCIS)) ;
Martínez García, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Quintana Ruiz, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Buitrago-Garcia, Diana (Universidad Tecnológica Equinoccial) ;
Lobos Urbina, D. (Pontificia Universidad Católica de Chile) ;
Cordero, José Antonio (Universitat Ramon Llull) ;
Universitat Autònoma de Barcelona
The purpose of this study was to provide evidence-based recommendations of intermittent androgen deprivation therapy (IADT) compared with continuous androgen deprivation therapy (CADT) for men with prostate cancer (PCA). [...]
2018 - 10.2147/CMAR.S164856
Cancer Management and Research, Vol. 10 (2018) , p. 2357-2367
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12 p, 813.5 KB |
Carotid blowout syndrome : Modern trends in management
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Suárez, C. (Universidad de Oviedo) ;
Fernández-Alvarez, Verónica (Hospital Universitario de Cabueñes (Gijón)) ;
Hamoir, Marc (St Luc University Hospital) ;
Mendenhall, W.M. (University of Florida) ;
Strojan, Primož (Institute of Oncology of Ljubljana) ;
Quer, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Silver, C.E. (University of Arizona) ;
Rodrigo, Juan Pablo (Hospital Universitario Central de Asturias) ;
Rinaldo, Alessandra (University of Udine School of Medicine) ;
Ferlito, Alfio (International Head and Neck Scientific Group) ;
Universitat Autònoma de Barcelona
Carotid blowout syndrome (CBS) refers to rupture of the carotid artery and is an uncommon complication of head and neck cancer that can be rapidly fatal without prompt diagnosis and intervention. CBS develops when a damaged arterial wall cannot sustain its integrity against the patient's blood pressure, mainly in patients who have undergone surgical procedures and radiotherapy due to cancer of the head and neck, or have been reirradiated for a recurrent or second primary tumor in the neck. [...]
2018 - 10.2147/CMAR.S180164
Cancer Management and Research, Vol. 10 (2018) , p. 5617-5628
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11 p, 639.3 KB |
Seroprevalence and immunological memory against SARS-CoV-2 in lung cancer patients : the SOLID study
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Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Rodríguez-Abreu, Delvys (Hospital Universitario Insular de Gran Canaria) ;
Ortega Granados, Ana Laura (Hospital Universitario de Jaén) ;
Serrano, Gloria (Hospital Universiario Infanta Leonor (Madrid)) ;
Aguado, Carlos (Hospital Clínico San Carlos (Madrid)) ;
Franco, Fernando (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Gutierrez, Vanesa (Hospital Universitario Regional de Málaga) ;
López-Vivanco, Guillermo (Hospital Universitario Cruces (Barakaldo, País Basc)) ;
Guirado Risueño, María (Hospital General Universitario de Elche) ;
Benítez, Gretel (Hospital Universitario Insular de Gran Canaria) ;
Estival, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Calvo, Virginia (Hospital Universitario Puerta de Hierro Majadahonda) ;
Jiménez, Beatriz (Hospital Universitario HM Sanchinarro (Madrid)) ;
Arasanz, Hugo (Complejo Hospitalario Navarra-Navarrabiomeed) ;
Coves, Juan (Hospital Universitari Son LLàtzer (Palma de Mallorca, Balears)) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Massutí, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Vázquez, Sergio (Hospital Universitario Lucus Augusti (Lugo)) ;
Juan, Óscar (Hospital Universitario y Politécnico La Fe) ;
Collazo-Lorduy, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Gozálvez, Clara L. (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Barco, Edel D. (Hospital Clínico Universitario (Salamanca)) ;
Rosero, Adriana (Hospital Universitario Infanta Cristina) ;
Bosch-Barrera, J. (Institut Català d'Oncologia) ;
Moreno, María A. (Hospital Universitario de Puerto Real (Cadis)) ;
Mielgo-Rubio, X. (Hospital Universitario Fundación Alcorcón) ;
Villa, J.C. (Hospital General Universitario Ciudad Real) ;
López-Martin, A. (Hospital Universitario Severo Ochoa) ;
Córdoba Ortega, Juan Felipe (Hospital Universitario Arnau de Vilanova) ;
de Asís Aparisi, F. (Hospital General Universitario de Valencia) ;
Zafra, M. (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Mosquera, J. (Complejo Hospitalario Universitario de A Coruña) ;
Altozano, J.P. (Hospital Virgen de los Lirios) ;
Nadal, E. (Institut Català d'Oncologia. Hospitalet de Llobregat) ;
Catot, S. (Altaia. Xarxa Assistencial Universitaria Manresa) ;
Balsalobre, J. (Hospital General Universitario Santa Lucia Cartagena) ;
de Portugal, T. (Complejo Hospitalario de Zamora) ;
Martín, P. (Hospital Clínic Universitari (València)) ;
de Juan, S.C. (Laboratorio Central) ;
Cobo, M. (Hospital Universitario Regional de Málaga) ;
Universitat Autònoma de Barcelona
At present, we did not find any articles that studied seroprevalence and its persistence several months later in lung cancer patients in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. [...]
2022 - 10.21037/tlcr-21-504
Translational Lung Cancer Research, Vol. 11 Núm. 1 (january 2022) , p. 53-63
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20 p, 1.6 MB |
Healthcare providers' adherence to breast cancer guidelines in Europe : a systematic literature review
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Niño de Guzmán, Ena Pery (Institut d'Investigació Biomèdica Sant Pau) ;
Song, Yang (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Canelo Aybar, Carlos Gilberto (Institut d'Investigació Biomèdica Sant Pau) ;
Neamtiu, L. (Joint Research Centre (JRC)) ;
Parmelli, Elena (European Commission. Joint Research Centre (JRC)) ;
Pérez-Bracchiglione, J. (Universidad de Valparaíso) ;
Rabassa Bonet, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Rigau, David (Institut d'Investigació Biomèdica Sant Pau) ;
Parkinson, Z.S. (Joint Research Centre (JRC)) ;
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Vásquez-Mejía, A. (Universidad Nacional Mayor de San Marcos (Lima, Perú)) ;
Ricci-Cabello, I. (Balearic Islands Health Service) ;
Universitat Autònoma de Barcelona
Clinical guidelines' (CGs) adherence supports high-quality care. However, healthcare providers do not always comply with CGs recommendations. This systematic literature review aims to assess the extent of healthcare providers' adherence to breast cancer CGs in Europe and to identify the factors that impact on healthcare providers' adherence. [...]
2020 - 10.1007/s10549-020-05657-8
Breast Cancer Research and Treatment, Vol. 181 Núm. 3 (january 2020) , p. 499-518
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